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Nearly forty years of Sargenti information has been published in a broad range of medical and legal journals from all over the world. The vast majority is written by unbiased medical researchers, practitioners and regulators whose findings are unfavorable to Sargenti type pastes and who are not all members of the American Association of Endodontists (AAE) as claimed by Sargenti proponents. Some are written by lawyers and doctors who have helped those victimized by no fault of their own. They, along with those victims, see the truths of Sargenti paste damage.
Research demonstrating the safety and efficacy of Sargenti pastes seems to originate from members or supporters of the American Endodontic Society (AES) and Sargenti himself. If neutral third-party and international studies have been conducted that validates the Sargenti proponents claim of safety, efficacy and superiority, then we request that they send us the documentation showing such.
We will gladly post the Phase II and Phase III approval documentation that the AES purports to have from the FDA. We do not understand why the AES does not put the nay-sayers to rest by providing the actual documentation to back up their claims.
General Topic |
Be Wary of Sargenti Root Canal Treatment, Barrett, Stephen, MD., Dental Watch, Nov. 2007 |
What is a Root canal, and Why Would Anyone Want One? Spiller, Martin, DMD, updated March 2008. |
| AAE position statement concerning paraformaldehyde-containing endodontic filling materials and sealers, 1998 |
| An injured patient's research on Sargenti Paste, Claudia Megaro, 2008 |
Sargenti Related Medical Studies and Publications From Throughout the World.
This is a very small sample of articles that can be found on the internet. Unfortunately, subscriptions are often
requried to read the entire article but when available, an abstract of the article is viewable by clicking on the document title.
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Country |
Paraformaldehyde Articlerch Title, Source and Link to Abstract |
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Unconventional Dentistry: Part I. Introduction, Burton H Goldstein, DMD, MS, FRCD(C), Journal of the Canadian Dental Association 2000; 66:323-6.Table 1 Classification of unconventional dental practices - IV Biologically Based Dental Therapies, Pharmacological, biological and instrumental interventions (e.g., Sargenti root canal treatment (N2); mandibular repositioning,
orthodontic treatment, electromyography, jaw tracking, thermography or sonography for TMD; neuralgia-inducing cavitational
osteonecrosis (NICO); urine therapy for toothache; “natural,” herbal, homeopathic, or synthetic dental products) |
Denmark
*NEW* |
Formaldehyde, which may be released from dental materials such as dental composites, glassionomer cements, and endodontic sealers, was used as test chemical.... Under identical experimental conditions, human target tissue cells appeared to be more sensitive to formaldehyde toxicity than human HeLa cancer cells. H. Lovschall. M. Eiskjaer and D. Arenholt-Bindslev, Tissue Culture Laboratory, Department of Dental Pathology, Operative Dentistry, and Endodontics, Royal Dental College, Faculty of Health Sciences, University of Aarhus, DK-8000 Aarhus C, Denmark. Toxicology in Vitro Volume 16, Issue 1, February 2002, Pages 63-69 |
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Anaphylactic reactions to formaldehyde in root canal sealant after endodontic treatment: four cases of anaphylactic shock and three of generalized urticaria [rash]. J J Braun, H Zana, A Purohit, J Valfrey, Ph Scherer, Y Haïkel, F de Blay, G Pauli, Allergy. 2003 Nov ;58 (11):1210-5 14616148. Service de Pneumologie, Hôpital Lyautey, Hôpitaux Universitaires de Strasbourg, BP 42, 67091 Strasbourg Cedex, France
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France |
IgE allergy due to formaldehyde paste during endodontic treatment. Apropos of 4 cases: 2 with anaphylactic shock and 2 with generalized urticaria, Geurtsen, Werner Dr Med Dent, PhD a; Leinenbach, Frank Dr Med Dent b; Krage, Tracey DMD c; Leyhausen, Gabriele Dr rer nat d Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontics. 85(5):592-597, May 1998. |
Germany |
Long-term cytocompatibility of various endodontic sealers using a new root canal model, Schwarze T, Leyhausen G, Geurtsen W. , Department of Conservative Dentistry & Periodontology, Medical University Hannover, Germany, Journal of Endodontics, 2002 Nov;28(11):749-53 |
Japan |
Anaphylaxis due to formaldehyde release from root-canal disinfectant, Kunisada M, Adachi A, Asano H, Horikawa, Contact Dermatitis. 2002 Oct;47(4):215-8 |
Italy |
Maxillary bone necrosis following the use of formaldehyde containing paste: management and case series, Br Dent J. 2007 Nov 10 |
Korea |
Chemically induced osteomyelitis in the mandible: A case report, Jee YJ, Song HC., Korean Assoc Maxillofac Plast Reconstr Surg. 2004 Jul;26(4):401-406. Korean |
Netherlands |
Formaldehyde in dental materials, Willemsen WL, Siers ML, Katholieke Universiteit Nijmegen, Postbus 9101, 6500 HB Nijmegen. |
Turkey |
Gingival necrosis following the use of a paraformaldehyde-containing paste: a case report, M. Özgöz, H. Yaiz, Y. Çiçek, A. Tezel (2004). International Endodontic Journal 37 (2) , 157–161 doi:10.1111/j.0143-2885.2004.00770.x |
Turkey |
To report that arsenic pastes are still employed in endodontics and to highlight the potentially serious consequences of their use, M. S. Yavuz, G. Şimşek Kaya, E. Yalçın, M. H. Aras, International Endodontic Journal, Volume 41 Issue 7 Page 633-637, July 2008 |
Sweden |
Bengtsson, Ulf, [Dental Materials In Endodontic Praxis. Ed 1.], LiTH-IKP-I-137. 1990. |
Norway
*NEW* |
D. 0RSTAVIK
NIOM — Scandinavian Institute of Dental Materials, Kirkeveien 71B, N-1344 Haslum, Norway, Endodontic Materials.
Endodontic sealing materials for permanent obturation of root canals are highly variable both in chemistry
of setting and in their additives. Conventional materials are based on zinc oxide-eugenol, rosinchloroform,
or synthetic resins. These have been extensively tested for biological and technical properties. Most
materials are slightly or moderately cytotoxic, and some — notably paraformaldehyde-containing materials —
have been associated with clinical complications such as paresthesia of the mental and/or inferior alveolar nerve. |
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Ardo Sabir.
Department of Conservative Dentistry,
Faculty of Dentistry Hasanuddin University
Makassar – Indonesia, Adv Dent Res 2(l):12-24, August, 1988, Root canal overfilling as an influencing factor for the success of
endodontic treatment.
Brodin et al. described quite a few overfilling cases with N2 or paraformaldehyde containing filling substance which displayed strong neurotoxic activity to generate permanent nerve damages. While several other writers wrote about the appearance of paresthesia of interior alveolaris nerves and a long stinging pain caused by root canal cement with paraformaldehyde. If the root canal filling substance (N2 or paraformaldehyde) makes overfilling, a quickest possible radical measure must be performed (endodontic surgery) to prevent the occurrence of nerve injury, since a nerve damage has no restoring process. |
Israel
*NEW* |
Etty Tagger, Michael Tagger, Nairn Sarnat, Department of Pediatric Dentistry, Chairman, Department of Endodontology, Chairman, Department of Pediatric Dentistry, School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Endodontics & Dental Traumatology, Vol 2, No 6, Pg 237 - 242, 1986, Pulpal reactions to glutaraldehyde and paraformaldehyde pulpotomy dressings in monkey primary teeth
SO: Endodontics & Dental Traumatology |
US |
Damage to the inferior alveolar nerve as the result of root canal therapy, M. Anthony Pogrel, J AM Dent Assoc 2007; 138;65-69 |
US |
Painful dysesthesia of the inferior alveolar nerve following use of a paraformaldehyde-containing root canal sealer, Donald J. Kleier, Robert E. Averbach (1988), Dental Traumatology 4 (1) , 46–48 doi:10.1111/j.1600-9657.1988.tb00293.x |
US |
Serious inferior alveolar nerve dysesthesia after endodontic procedure: report of three cases, LaBanc JP, Epker BN, J Am Dent Assoc. 1984 Apr;108(4):605-7 |
US |
Studies of Sargenti's technique of endodontic treatment: six-month and one-year responses, Carl W. Newton, DDS, MSD, Sauel S. Patterson, DDS, MSD Abdel H. Kafrawy, BDS, MSD, Journal of Endodontics, Volume 6, Issue 4, Pages 509-517 (April 1980) |
US |
Formaldehyde in dentistry: a review of mutagenic and carcinogenic potential, BB Lewis and SB Chestner, Journal of the American Dental Association, Vol 103, Issue 3, 429-434 |
US |
Cytotoxicity of four root canal sealers in permanent 3T3 cells and primary human periodontal ligament fibroblast cultures. Geurtsen, Werner Dr Med Dent, PhD a; Leinenbach, Frank Dr Med Dent b; Krage, Tracey DMD c; Leyhausen, Gabriele Dr rer nat d Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontics. 85(5):592-597, May 1998. |
US |
Veterinary Dentistry: Principles and Practice, Robert B. Wiggs, Heide B. Lobprise, 1997, pg. 314 |
US |
Systemic distribution of N2 paste containing 14C paraformaldehyde following root canal therapy in dogs, Block RM, Lewis RD, Hirsch J, Coffey J, Langeland KOral Surgery Oral Medicine Oral Pathology, 1980 Oct; 50(4):350-60 |
US |
Toxicity of endodontic filling materials, Jon E. Dahl, Endodontic Topics 2005, 12, 39-43. |
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Sargenti, The Law and Ethics |
US. Endodontics and the Law, Cohen, Stephen, DDS., Contemporary Endodontics, Vol. 1, No. 1, 2004.
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Pending additional documentation...
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Injured patients should file an adverse event report with the FDA. Absent reports from the public, the FDA will not realize the extent of the dangers of Sargent Paste. Click here to file report. Also ask your doctor to file a report on your behalf. Since reports are voluntary over 90% of adverse events go unreported.